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      <link:linkbaseRef xlink:type="simple" xlink:href="rsls-20240630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="rsls-20240630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:roleType roleURI="http://www.reshapelifesciences.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
        <link:definition>99900 - Disclosure - Standard And Custom Axis Domain Defaults</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="rsls_ClassOfWarrantOrRightCancelledInPeriod" xbrli:periodType="duration" name="ClassOfWarrantOrRightCancelledInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightExercisedInPeriod" xbrli:periodType="duration" name="ClassOfWarrantOrRightExercisedInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightExercisesInPeriodWeightedAverageExercisePriceOfWarrantsOrRights" xbrli:periodType="instant" name="ClassOfWarrantOrRightExercisesInPeriodWeightedAverageExercisePriceOfWarrantsOrRights" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightGrantsInPeriod" xbrli:periodType="duration" name="ClassOfWarrantOrRightGrantsInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_IncomeTaxesLineItems" xbrli:periodType="duration" abstract="true" name="IncomeTaxesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="rsls_IncomeTaxesTable" xbrli:periodType="duration" abstract="true" name="IncomeTaxesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="rsls_LiabilitiesAndShareholdersEquityAbstract" xbrli:periodType="duration" abstract="true" name="LiabilitiesAndShareholdersEquityAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="rsls_LiquidityAndManagementsPlansLineItems" xbrli:periodType="duration" abstract="true" name="LiquidityAndManagementsPlansLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="rsls_LiquidityAndManagementsPlansTable" xbrli:periodType="duration" abstract="true" name="LiquidityAndManagementsPlansTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="rsls_MoneyMarketValuePerShare" xbrli:periodType="duration" name="MoneyMarketValuePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="rsls_StockWarrantsDisclosureTextBlock" xbrli:periodType="duration" name="StockWarrantsDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="rsls_PercentageOfOwnershipChangeInOutstandingStock" xbrli:periodType="duration" name="PercentageOfOwnershipChangeInOutstandingStock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_SeriesCConvertiblePreferredStockMember" xbrli:periodType="duration" abstract="true" name="SeriesCConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ReshapeVblocProductMember" xbrli:periodType="duration" abstract="true" name="ReshapeVblocProductMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ComputerEquipmentAndSoftwareMember" xbrli:periodType="duration" abstract="true" name="ComputerEquipmentAndSoftwareMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_LapBandProductLineMember" xbrli:periodType="duration" abstract="true" name="LapBandProductLineMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsTableTextBlock" xbrli:periodType="duration" name="ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="rsls_StockIssuedDuringPeriodSharesWarrantsExercised" xbrli:periodType="duration" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_PeriodForSalesReturn" xbrli:periodType="duration" name="PeriodForSalesReturn" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="rsls_ReverseStockSplitsPolicyPolicyTextBlock" xbrli:periodType="duration" name="ReverseStockSplitsPolicyPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="rsls_ScheduleOfAssetsAndLiabilitiesAndCashFlowLesseeOperatingLeaseTableTextBlock" xbrli:periodType="duration" name="ScheduleOfAssetsAndLiabilitiesAndCashFlowLesseeOperatingLeaseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="rsls_SubstantialDoubtAboutGoingConcernAbstract" xbrli:periodType="duration" abstract="true" name="SubstantialDoubtAboutGoingConcernAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="rsls_ReshapeLifesciencesIncorporatedSecondAmendedAndRestated2003StockIncentivePlanMember" xbrli:periodType="duration" abstract="true" name="ReshapeLifesciencesIncorporatedSecondAmendedAndRestated2003StockIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_StandardProductWarrantyTerm" xbrli:periodType="duration" name="StandardProductWarrantyTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="rsls_WorkingCapital" xbrli:periodType="instant" xbrli:balance="debit" name="WorkingCapital" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_IntangibleAssetsFairValueDiscountRate" xbrli:periodType="duration" name="IntangibleAssetsFairValueDiscountRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_WarrantLiabilityCurrent" xbrli:periodType="instant" xbrli:balance="credit" name="WarrantLiabilityCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_IncreaseDecreaseInWarrantLiability" xbrli:periodType="duration" xbrli:balance="debit" name="IncreaseDecreaseInWarrantLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_SeveranceBenefitsPayable" xbrli:periodType="instant" xbrli:balance="credit" name="SeveranceBenefitsPayable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_AccruedPerformanceBonuses" xbrli:periodType="instant" xbrli:balance="credit" name="AccruedPerformanceBonuses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_BlackScholesModelMember" xbrli:periodType="duration" abstract="true" name="BlackScholesModelMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_MonteCarloSimulationModelMember" xbrli:periodType="duration" abstract="true" name="MonteCarloSimulationModelMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ScheduleOfWarrantAssumptionsUsedToCalculateFairValueTableTextBlock" xbrli:periodType="duration" name="ScheduleOfWarrantAssumptionsUsedToCalculateFairValueTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="rsls_RegisteredDirectOfferingMember" xbrli:periodType="duration" abstract="true" name="RegisteredDirectOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_RestockingFee" xbrli:periodType="duration" name="RestockingFee" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_CommonStockNoClassMember" xbrli:periodType="duration" abstract="true" name="CommonStockNoClassMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_StockAndWarrantsIssuedDuringPeriodSharesInstitutionalExerciseOfWarrants" xbrli:periodType="duration" name="StockAndWarrantsIssuedDuringPeriodSharesInstitutionalExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_StockAndWarrantsIssuedDuringPeriodValueInstitutionalExerciseOfWarrants" xbrli:periodType="duration" xbrli:balance="credit" name="StockAndWarrantsIssuedDuringPeriodValueInstitutionalExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_DeferredTaxAssetsStartUpCosts" xbrli:periodType="instant" xbrli:balance="debit" name="DeferredTaxAssetsStartUpCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_DeferredTaxAssetsCapitalizedResearchAndDevelopmentCosts" xbrli:periodType="instant" xbrli:balance="debit" name="DeferredTaxAssetsCapitalizedResearchAndDevelopmentCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_DeferredTaxAssetLeaseLiability" xbrli:periodType="instant" xbrli:balance="debit" name="DeferredTaxAssetLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_Effectiveincometaxratereconciliationdeductionsstockwarrantvaluation" xbrli:periodType="duration" name="Effectiveincometaxratereconciliationdeductionsstockwarrantvaluation" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_NewUnregisteredWarrantsMember" xbrli:periodType="duration" abstract="true" name="NewUnregisteredWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightNewWarrantsAsPercentageOfCommonStockIssuedForWarrantsExercised" xbrli:periodType="instant" name="ClassOfWarrantOrRightNewWarrantsAsPercentageOfCommonStockIssuedForWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightCashPurchasePricePerShare" xbrli:periodType="instant" name="ClassOfWarrantOrRightCashPurchasePricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="rsls_ObalonTherapeuticsInc.Member" xbrli:periodType="duration" abstract="true" name="ObalonTherapeuticsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndUndistributedDuringPeriod" xbrli:periodType="duration" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndUndistributedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_EffectiveIncomeTaxRateReconciliationNetOperatingLossAdjustmentPercent" xbrli:periodType="duration" name="EffectiveIncomeTaxRateReconciliationNetOperatingLossAdjustmentPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_AccountsReceivablePaymentPeriod" xbrli:periodType="duration" name="AccountsReceivablePaymentPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="rsls_CowenAndCompanyLlcMember" xbrli:periodType="duration" abstract="true" name="CowenAndCompanyLlcMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_LossContingencyServiceFeesSoughtValue" xbrli:periodType="duration" xbrli:balance="debit" name="LossContingencyServiceFeesSoughtValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_IndefiniteLivedIntangibleAssetsExcludingGoodwillBeforeImpairment" xbrli:periodType="instant" xbrli:balance="debit" name="IndefiniteLivedIntangibleAssetsExcludingGoodwillBeforeImpairment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_ClassOfWarrantInvestorsIssuedJune2022Member" xbrli:periodType="duration" abstract="true" name="ClassOfWarrantInvestorsIssuedJune2022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_AccruedLegalLiabilitiesCurrent" xbrli:periodType="instant" xbrli:balance="credit" name="AccruedLegalLiabilitiesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_SecuritiesPurchaseAgreementMember" xbrli:periodType="duration" abstract="true" name="SecuritiesPurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_WarrantAmendmentAgreementMember" xbrli:periodType="duration" abstract="true" name="WarrantAmendmentAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_SeriesDMirroringPreferredStockMember" xbrli:periodType="duration" abstract="true" name="SeriesDMirroringPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PreFundedWarrantsMember" xbrli:periodType="duration" abstract="true" name="PreFundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PrivatePlacementWarrantsMember" xbrli:periodType="duration" abstract="true" name="PrivatePlacementWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_WarrantsAndRightsExpiryTerm" xbrli:periodType="duration" name="WarrantsAndRightsExpiryTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="rsls_PreferredStockCancelledDuringPeriodShares" xbrli:periodType="duration" name="PreferredStockCancelledDuringPeriodShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_PreferredStockCancelledDuringPeriodValue" xbrli:periodType="duration" xbrli:balance="debit" name="PreferredStockCancelledDuringPeriodValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_ReloadWarrantsMember" xbrli:periodType="duration" abstract="true" name="ReloadWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CommonStockPurchaseWarrantsMember" xbrli:periodType="duration" abstract="true" name="CommonStockPurchaseWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_RepresentativesWarrantsMember" xbrli:periodType="duration" abstract="true" name="RepresentativesWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_IrvineCaliforniaOfficeAndWarehouseSpaceMember" xbrli:periodType="duration" abstract="true" name="IrvineCaliforniaOfficeAndWarehouseSpaceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_DbsnDeviceMember" xbrli:periodType="duration" abstract="true" name="DbsnDeviceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_TwentyTwentyTwoEquityIncentivePlanMember" xbrli:periodType="duration" abstract="true" name="TwentyTwentyTwoEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_NumberOfUnitsIssuedDuringPeriodNewIssues" xbrli:periodType="duration" name="NumberOfUnitsIssuedDuringPeriodNewIssues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_PublicOfferingMember" xbrli:periodType="duration" abstract="true" name="PublicOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_NumberOfSharesForEachUnit" xbrli:periodType="duration" name="NumberOfSharesForEachUnit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_NumberOfWarrantsForEachUnit" xbrli:periodType="duration" name="NumberOfWarrantsForEachUnit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_PublicWarrantsMember" xbrli:periodType="duration" abstract="true" name="PublicWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_LitigationSettlementInterestPercent" xbrli:periodType="duration" name="LitigationSettlementInterestPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_WarrantsCashlessExerciseProvisionSharesMultiplier" xbrli:periodType="duration" name="WarrantsCashlessExerciseProvisionSharesMultiplier" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" />
  <xsd:element id="rsls_GrossProceedsFromIssuanceOfCommonStock" xbrli:periodType="duration" xbrli:balance="debit" name="GrossProceedsFromIssuanceOfCommonStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_ReloadWarrantsJune2022Member" xbrli:periodType="duration" abstract="true" name="ReloadWarrantsJune2022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ReloadWarrantsNovember2022Member" xbrli:periodType="duration" abstract="true" name="ReloadWarrantsNovember2022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PreferredStockIssuedDuringPeriodValue" xbrli:periodType="duration" xbrli:balance="debit" name="PreferredStockIssuedDuringPeriodValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_PreferredStockIssuedDuringPeriodShares" xbrli:periodType="duration" name="PreferredStockIssuedDuringPeriodShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_CommonStockWarrantsWithAlternativeCashlessExerciseMember" xbrli:periodType="duration" abstract="true" name="CommonStockWarrantsWithAlternativeCashlessExerciseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_StockIssuedDuringPeriodValueReverseStockSplits" xbrli:periodType="duration" xbrli:balance="credit" name="StockIssuedDuringPeriodValueReverseStockSplits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_PrepaidPatentExpenseCurrent" xbrli:periodType="instant" xbrli:balance="debit" name="PrepaidPatentExpenseCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_AggregateNumberOfSharesIssuedWarrantsExercised" xbrli:periodType="duration" name="AggregateNumberOfSharesIssuedWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_LitigationSettlementAttorneyFeesPayable" xbrli:periodType="instant" xbrli:balance="credit" name="LitigationSettlementAttorneyFeesPayable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_LitigationSettlementPaymentsOfAttorneyFeesTrancheOne" xbrli:periodType="duration" xbrli:balance="credit" name="LitigationSettlementPaymentsOfAttorneyFeesTrancheOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_LitigationSettlementPaymentsOfAttorneyFeesTrancheTwo" xbrli:periodType="duration" xbrli:balance="credit" name="LitigationSettlementPaymentsOfAttorneyFeesTrancheTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_LitigationSettlementPaymentsOfAttorneyFeesTrancheThree" xbrli:periodType="duration" xbrli:balance="credit" name="LitigationSettlementPaymentsOfAttorneyFeesTrancheThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_LossContingencyAccrualAttorneyFees" xbrli:periodType="instant" xbrli:balance="credit" name="LossContingencyAccrualAttorneyFees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_SecuritiesOfferingCostsPercentageOfGrossProceeds" xbrli:periodType="duration" name="SecuritiesOfferingCostsPercentageOfGrossProceeds" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_WarrantsIssuedPercentageOfAggregateAmountOfCommonShares" xbrli:periodType="duration" name="WarrantsIssuedPercentageOfAggregateAmountOfCommonShares" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_AmendedWarrantsMember" xbrli:periodType="duration" abstract="true" name="AmendedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CashExerciseMember" xbrli:periodType="duration" abstract="true" name="CashExerciseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CashlessExerciseMember" xbrli:periodType="duration" abstract="true" name="CashlessExerciseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityExercisesOfWarrants" xbrli:periodType="duration" xbrli:balance="debit" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityExercisesOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_LitigationSettlementFirstInstallment" xbrli:periodType="instant" xbrli:balance="credit" name="LitigationSettlementFirstInstallment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_OfferingCost" xbrli:periodType="duration" xbrli:balance="debit" name="OfferingCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_AdjustmentsToAdditionalPaidInCapitalStockOfferingCosts" xbrli:periodType="duration" xbrli:balance="credit" name="AdjustmentsToAdditionalPaidInCapitalStockOfferingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityValueInExcessOfProceeds" xbrli:periodType="instant" xbrli:balance="debit" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityValueInExcessOfProceeds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_CommonWarrantsMember" xbrli:periodType="duration" abstract="true" name="CommonWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_OneOfInvestorsMember" xbrli:periodType="duration" abstract="true" name="OneOfInvestorsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ExistingWarrantsMember" xbrli:periodType="duration" abstract="true" name="ExistingWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_InvestmentInWarrantsMember" xbrli:periodType="duration" abstract="true" name="InvestmentInWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_LiabilityWarrantMember" xbrli:periodType="duration" abstract="true" name="LiabilityWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_RepresentativeSWarrantsFebruary2023Member" xbrli:periodType="duration" abstract="true" name="RepresentativeSWarrantsFebruary2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CommonStockWarrantsApril2023Member" xbrli:periodType="duration" abstract="true" name="CommonStockWarrantsApril2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PreFundedWarrantsApril2023Member" xbrli:periodType="duration" abstract="true" name="PreFundedWarrantsApril2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_RepresentativeSWarrantsApril2023Member" xbrli:periodType="duration" abstract="true" name="RepresentativeSWarrantsApril2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CommonStockWarrantsOctober2023Member" xbrli:periodType="duration" abstract="true" name="CommonStockWarrantsOctober2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PreFundedWarrantsOctober2023Member" xbrli:periodType="duration" abstract="true" name="PreFundedWarrantsOctober2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_RepresentativeSWarrantsOctober2023Member" xbrli:periodType="duration" abstract="true" name="RepresentativeSWarrantsOctober2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_CommonStockWarrantsNovember2023Member" xbrli:periodType="duration" abstract="true" name="CommonStockWarrantsNovember2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_Indefinitelivedintangibleassetaccumulatedamortization" xbrli:periodType="instant" xbrli:balance="credit" name="Indefinitelivedintangibleassetaccumulatedamortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_PreFundedWarrantsFebruary2023Member" xbrli:periodType="duration" abstract="true" name="PreFundedWarrantsFebruary2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ShareBasedCompensationArrangementByShareBasedPaymentAwardUnissued" xbrli:periodType="duration" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardUnissued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_PrepaidProfessionalServices" xbrli:periodType="instant" xbrli:balance="debit" name="PrepaidProfessionalServices" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_ObalonBalloonSystemMember" xbrli:periodType="duration" abstract="true" name="ObalonBalloonSystemMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_WarrantsIssuedShares" xbrli:periodType="duration" name="WarrantsIssuedShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="rsls_MergerAgreementMember" xbrli:periodType="duration" abstract="true" name="MergerAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightFairValueDisclosure" xbrli:periodType="instant" xbrli:balance="credit" name="ClassOfWarrantOrRightFairValueDisclosure" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_NumberOfClassesOfWarrants" xbrli:periodType="instant" name="NumberOfClassesOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="rsls_ClassOfWarrantOrRightIssuePricePerWarrant" xbrli:periodType="instant" name="ClassOfWarrantOrRightIssuePricePerWarrant" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="rsls_NumberOfInvestors" xbrli:periodType="duration" name="NumberOfInvestors" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="rsls_AssetPurchaseAgreementMember" xbrli:periodType="duration" abstract="true" name="AssetPurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="rsls_PreferredStockLiquidationValueAsPercentageOfAssetPurchasePrice" xbrli:periodType="instant" name="PreferredStockLiquidationValueAsPercentageOfAssetPurchasePrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_InvestorCommitmentToPurchaseSharesValue" xbrli:periodType="duration" xbrli:balance="debit" name="InvestorCommitmentToPurchaseSharesValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="rsls_CommonStockPriceDiscountPercentageBasedOnValuationAtMergerClosing" xbrli:periodType="instant" name="CommonStockPriceDiscountPercentageBasedOnValuationAtMergerClosing" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_ConvertiblePromissoryNotePrincipalAsPercentageOfInvestmentAmount" xbrli:periodType="instant" name="ConvertiblePromissoryNotePrincipalAsPercentageOfInvestmentAmount" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_DebtConversionPercentageOfCarryingValueConvertedIntoCommonStock" xbrli:periodType="instant" name="DebtConversionPercentageOfCarryingValueConvertedIntoCommonStock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="rsls_SaleOfStockByVyomeTherapeuticsMember" xbrli:periodType="duration" abstract="true" name="SaleOfStockByVyomeTherapeuticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
</xsd:schema>